MDC1 Antibody

• Background :

  The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

• NCBI Gene ID :

  9656

• Swiss Prot :

  Q14676

• Host :

  Rabbit

• Reactivity :

  Mouse

• Immunogen :

  A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MDC1 (NP_055456.2) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  Affinity purification

• Positive Control :

  Mouse testis

• Concentration :

  Batch dependent

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  Observed: 226kDa

• Fragment :

  IgG

• Applications Notes :

  WB: 1:500 - 1:2000

• Symbol :

  MDC1

• NCBI Official Name :

  Mediator of DNA-damage checkpoint 1

• NCBI Organism :

  Homo sapiens

• Other Product Names :

  IER3, NFBD1, KIAA0170, DKFZp781A0122

• Tested Applications :

  WB

• Physical Properties :

  Liquid