MDC1 Antibody

• Background:

  The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

• NCBI Gene ID:

  9656

• Swiss Prot:

  Q14676

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  A synthetic peptide corresponding to a sequence within amino acids 1-100 of human MDC1 (NP_055456.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Affinity purification

• Positive Control:

  Mouse testis

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 226kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  MDC1

• NCBI Official Name:

  Mediator of DNA-damage checkpoint 1

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  IER3, NFBD1, KIAA0170, DKFZp781A0122

• Tested Applications:

  WB

• Physical Properties:

  Liquid