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E2A (phospho Thr355) Antibody

CAT: 0223-79-908Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-908Size:0.1 mg
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Background
E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described.
NCBI Gene ID
6929
Swiss Prot
P15923
Accession Number
NP_003191.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E2A (phospho Thr355) antibody was raised against a peptide sequence around phosphorylation site of threonine 355 (P-S-T (p) -P-V) derived from Human E2A .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
67 kDa
Fragment
IgG
Specificity
The antibody detects endogenous levels of E2A only when phosphorylated at threonine 355.
Symbol
TCF3
NCBI Official Name
Transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)
NCBI Organism
Homo sapiens
Background Reference 01
Kamps M.P., Cell 60:547-555 (1990) .
Background Reference 02
Nourse J., Cell 60:535-545 (1990) .
Background Reference 03
Grimwood J., Nature 428:529-535 (2004) .
Other Product Names
E12, Tran, TCF3, TFE2, ITF1
Tested Applications
IHC
Protein ID
27777636
Physical Properties
Liquid

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