MAP2K7 (phospho Ser271) Antibody

• Background:

  The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

• NCBI Gene ID:

  5609

• Swiss Prot:

  O14733

• Accession Number:

  NP_660186.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  MAP2K7 (phospho Ser271) antibody was raised against a peptide sequence around phosphorylation site of Serine271 (V-D-S (p) -K-A) derived from Human MAP2K7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  60 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of MAP2K7 only when phosphorylated at serine 271.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

• Symbol:

  MAP2K7

• NCBI Official Name:

  Mitogen-activated protein kinase kinase 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wu Z., Mol. Cell. Biol. 17:7407-7416 (1997) .

• Background Reference 02:

  Lu X., J. Biol. Chem. 272:24751-24754 (1997) .

• Background Reference 03:

  Foltz I.N., J. Biol. Chem. 273:9344-9351 (1998) .

• Other Product Names:

  PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7

• Tested Applications:

  WB, IHC

• Protein ID:

  21735544

• Physical Properties:

  Liquid