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MAP2K7 (phospho Ser271) Antibody

CAT: 0223-79-855Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-855Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
NCBI Gene ID
5609
Swiss Prot
O14733
Accession Number
NP_660186.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MAP2K7 (phospho Ser271) antibody was raised against a peptide sequence around phosphorylation site of Serine271 (V-D-S (p) -K-A) derived from Human MAP2K7.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
60 kDa
Fragment
IgG
Specificity
The antibody detects endogenous levels of MAP2K7 only when phosphorylated at serine 271.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
MAP2K7
NCBI Official Name
Mitogen-activated protein kinase kinase 7
NCBI Organism
Homo sapiens
Background Reference 01
Wu Z., Mol. Cell. Biol. 17:7407-7416 (1997) .
Background Reference 02
Lu X., J. Biol. Chem. 272:24751-24754 (1997) .
Background Reference 03
Foltz I.N., J. Biol. Chem. 273:9344-9351 (1998) .
Other Product Names
PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7
Tested Applications
WB, IHC
Protein ID
21735544
Physical Properties
Liquid

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