IKK-γ (phospho Ser376) Antibody

• Background:

  Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.

• NCBI Gene ID:

  8517

• Swiss Prot:

  Q9Y6K9

• Accession Number:

  NP_001093327.1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  IKK-γ (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Y-L-S (p) -S-P) derived from Human IKK-γ.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Phospho-Specific

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  Phospho-Specific

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  IgG

• Specificity:

  The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.

• Symbol:

  IKBKG

• NCBI Official Name:

  Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047 (1999) .

• Background Reference 02:

  Jin D.-Y., J. Biomed. Sci. 6:115-120 (1999) .

• Background Reference 03:

  Rothwarf D.M., Nature 395:297-300 (1998) .

• Other Product Names:

  FIP3, IKBKG, IKKAP1, IKKG, NF-kappaB

• Tested Applications:

  IHC

• Protein ID:

  3641279

• Physical Properties:

  Liquid