IKK alpha Antibody

CAT: 0223-2117-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-2117-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IKK alpha Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and bacteria product LPS. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. The long-sought Iκ B kinase (IKK), which phosphorylates Iκ B, and mediates Iκ B degradation and NF-κ B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ ) . IKKα and IKKβ interact with each other and both are essential for the NF-κ B activation. IKKα specifically phosphorylates Iκ B-alpha. IKKα is expressed in a variety of human tissues.
NCBI Gene ID
1147
Swiss Prot
O15111
Accession Number
AF009225
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
IKK alpha Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (100%)
Buffer
IKK alpha Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IKK alpha antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
Observed: 87 kDa
Fragment
IgG
Specificity
This polyclonal antibody has no cross response to IKKb or IKKy.
Symbol
CHUK
Positive Control 2
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 3
Cat. No. 17-005 - Jurkat Cell Slide
NCBI Official Name
Conserved helix-loop-helix ubiquitous kinase
NCBI Organism
Homo sapiens
Background Reference 01
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive Iκ B kinase that activates the transcription factor NF-κ B. Nature 1997;388:548-54
Background Reference 02
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an Iκ B kinase. Cell 1997;90:373-83
Background Reference 03
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The Iκ B kinase complex (IKK) contains two kinase subunits, IKKα and IKKα , necessary for Iκ B phosphorylation and NF-κ B activation. Cell 1997;91:243-52
Background Reference 04
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DY. Iκ B kinase-β : NF-κ B activation and complex formation with Iκ B kinase-α and NIK. Science 1997;278:866-9
Other Product Names
IKK alpha Antibody: IKK1, IKKA, IKBKA, TCF16, NFKBIKA, IKK-alpha, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase alpha
Tested Applications
ELISA, WB, ICC
Protein ID
2327068
Physical Properties
Liquid

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