Products for Research Use Only
RegisterLogin

IKK beta Antibody

CAT: 0223-2121-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-2121-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
IKK beta Antibody: Nuclear factor kappa B (NF-κ B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κ B mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα , and bacteria product LPS. NF-κ B is associated with Iκ B proteins in the cell cytoplasm, which inhibit NF-κ B activity. The long-sought Iκ B kinase (IKK), which phosphorylates Iκ B, and mediates Iκ B degradation and NF-κ B activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ ) . IKKα and IKKβ interact with each other and both are essential for NF-κ B activation. IKKβ phosphorylates both Iκ B-alpha and Iκ B-beta. IKKβ is expressed in variety of human tissues.
NCBI Gene ID
3551
Swiss Prot
O14920
Accession Number
O14920
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
IKK beta Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/ml
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rat: (95%), Mouse: (95%)
Buffer
IKK beta Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IKK beta antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
87 kDa
Fragment
IgG
Specificity
This polyclonal antibody has no cross response to IKKa or IKKy.
Symbol
IKBKB
Positive Control 2
Cat. No. 1201 - HeLa Cell Lysate
Positive Control 3
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
NCBI Organism
Homo sapiens
Background Reference 01
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive Iκ B kinase that activates the transcription factor NF-κ B. Nature 1997;388:548-54
Background Reference 02
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an Iκ B kinase. Cell 1997;90:373-83
Background Reference 03
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The Iκ B kinase complex (IKK) contains two kinase subunits, IKKα and IKKα , necessary for Iκ B phosphorylation and NF-κ B activation. Cell 1997;91:243-52
Background Reference 04
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DY. Iκ B kinase-β : NF-κ B activation and complex formation with Iκ B kinase-α and NIK. Science 1997;278:866-9
Other Product Names
IKK beta Antibody: IKK2, IKKB, IMD15, NFKBIKB, IKK-beta, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, I-kappa-B-kinase beta
Tested Applications
ELISA, WB, ICC, IF
Protein ID
14285497
Physical Properties
Liquid

Related Products

CatalogName
79-980IKK- beta (phospho Tyr188) Antibody
79-613IKK beta (Ab 199) Antibody
2121PIKK beta (C3) Peptide
79-982IKK- alpha/ beta (phospho Ser176/177) Antibody
2115-002mgIKK alpha Antibody
2117-01IKK alpha Antibody
2329-002mgIKK epsilon Antibody
2025-002mgIKK alpha Antibody
2329-01mgIKK epsilon Antibody
18-473IKK alpha Antibody

Alternative Products

CatalogName
GTR17854267S-100 (beta-beta & alpha1-beta) Antibody
GTR17974444BetA Antibody
GWB-A9A3DDS-100 Antibody (beta-beta)
abx008721-01Beta Sarcoglycan (beta sarcoglycan) Antibody
OAMA01890-1MGS-100 beta-beta Antibody
F55073-0.05MLChoriogonadotropin beta Antibody / HCG-beta
GTR18793374Beta Lipotropin (Beta-LPH) Antibody
OAMA01893-1MGS-100 (beta-beta) Antibody
GTR18224321IFN Beta/Interferon Beta Antibody
OAMA01891-1MGS-100 beta-beta and alpha-1-beta Antibody

Popular Products