TRPC6 Antibody

• Background:

  The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2) .

• NCBI Gene ID:

  7225

• Swiss Prot:

  Q61143

• Accession Number:

  NP_004612.2

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  TRPC6 antibodypeptide Corresponding to the amino terminal sequence derived from mouse TRPC6.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  100 kDa

• Specificity:

  This antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  TRPC6

• NCBI Official Name:

  Transient receptor potential cation channel, subfamily C, member 6

• NCBI Organism:

  Peptide Corresponding to the amino terminal sequence derived from mouse TRPC6.

• Background Reference 01:

  Koichiro Kuwahara et al. (2006) J Clin Invest. 116 (12) : 3114–3126. Mark Estacion et al. (2006) J Physiol. 2006, 572 (Pt 2) : 359–377. Maria A et al. (2006) Proc Natl Acad Sci U S A. 103 (44) : 16586–16591.

• Other Product Names:

  TRP6, FSGS2, TRP6, FLJ11098

• Tested Applications:

  WB

• Protein ID:

  5730102

• Physical Properties:

  Liquid