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A Synuclein (Ab 129) Antibody

CAT: 0223-79-570Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-570Size:0.1 mg
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Background
SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons
NCBI Gene ID
6622
Swiss Prot
P37840
Accession Number
NP_000336.1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A-Synuclein (Ab-129) antibody was raised against a peptide sequence around aa.127~131 (M-P-S-E-E) derived from Human α -Synuclein.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
18 kDa
Specificity
This antibody detects endogenous level of total Synuclein protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
SNCA
NCBI Official Name
Synuclein, alpha (non A4 component of amyloid precursor)
NCBI Organism
Homo sapiens
Background Reference 01
Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
Other Product Names
PD1, NACP, PARK1, PARK4, SYN, SYUA, alpha-synuclein
Tested Applications
WB
Protein ID
4507109
Physical Properties
Liquid

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