A Synuclein (Ab 133) Antibody

• Background:

  May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies) . Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.

• NCBI Gene ID:

  6622

• Swiss Prot:

  P37840

• Accession Number:

  NP_000336.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A-Synuclein (Ab-133) antibody was raised against a peptide sequence around aa. 131~135 (E-G-Y-Q-D) derived from Human α -Synuclein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  18 kDa

• Specificity:

  This antibody detects endogenous level of total Synuclein protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

• Symbol:

  SNCA

• NCBI Official Name:

  Synuclein, alpha (non A4 component of amyloid precursor)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Kozikowski AP, et al. (2006) ChemMedChem. 1 (2) : 256-66. Jakowec MW, et al. (2001) Dev Neurosci. 23 (2) : 91-9. El-Agnaf OM, et al. (1998) FEBS Lett. 440 (1-2) : 67-70.

• Other Product Names:

  PD1, NACP, PARK1, PARK4, SYN, SYUA, alpha-synuclein

• Tested Applications:

  WB, IF

• Protein ID:

  4507109

• Physical Properties:

  Liquid