A Synuclein (Ab 125) Antibody

• Background:

  SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

• NCBI Gene ID:

  6622

• Swiss Prot:

  P37840

• Accession Number:

  NP_000336.1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A-Synuclein (Ab-125) antibody was raised against a peptide sequence around aa.123~127 (E-A-Y-E-M) derived from Human α -Synuclein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  18 kDa

• Specificity:

  This antibody detects endogenous level of total Synuclein protein.

• Applications Notes:

  Western Blot: 1:500~1:1000

• Symbol:

  SNCA

• NCBI Official Name:

  Synuclein, alpha (non A4 component of amyloid precursor)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43) : 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14) : 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2) : 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.

• Other Product Names:

  PD1, NACP, PARK1, PARK4, CDKN6, SYN, SYUA, alpha-synuclein

• Tested Applications:

  WB

• Protein ID:

  4507109

• Physical Properties:

  Liquid