CD197 Antibody [3D12] (FITC)

• Background:

  The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled. It is the receptor for the secondary lymphoid-tissue chemokine (SLC or 6CKine), CCL19, and CCL21. CD197 is expressed on subsets of B and T cells, and mature dendritic cells. The monoclonal 3D12 antibody recognizes the N-terminus of the receptor.

• NCBI Gene ID:

  1236

• Swiss Prot:

  P32248

• Host:

  Mouse

• Reactivity:

  Human

• Clonality:

  Monoclonal

• Clone:

  3D12

• Conjugation:

  FITC

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Chemokines & Cytokines, Growth Factors

• Purification:

  The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

• Concentration:

  Batch dependent

• Buffer:

  Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.

• Fragment:

  Mouse IgG1, kappa

• Specificity:

  The 3D12 monoclonal antibody specifically reacts with human CD197 (CCR7 or EBI-1), a seven-transmembrane G-protein-coupled.

• Symbol:

  CCR7

• NCBI Official Name:

  Chemokine (C-C motif) receptor 7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Sallusto, F., Lenig, D., Frster, R., Lipp, M., Lanzavecchia, A. (1999) . Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.Nature,401 (6754), 708-712.

• Background Reference 02:

  Yoshida, R., Nagira, M., Imai, T., Baba, M., Takagi, S., Tabira, Y., ... Yoshie, O. (1998) . EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC.International immunology,10 (7), 901-910.

• Background Reference 03:

  Lee, N., Llano, M., Carretero, M., Ishitani, A., Navarro, F., Lpez-Botet, M., Geraghty, D. E. (1998) . HLA-E is a major ligand for the natural killer inhibitory receptor CD94/NKG2A.Proceedings of the National Academy of Sciences,95 (9), 5199-5204.

• Other Product Names:

  BLR2, EBI1, CCR-7, CD197, CDw197, CMKBR7, CC-CKR-7, CCR7

• Tested Applications:

  Flow

• Physical Properties:

  Liquid