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CD11b Antibody [M1/70]

CAT: 0223-76-116Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-116Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) . Mac-1 binds to C3bi, CD54 (ICAM-1), and fibrinogen, and it is expressed by granulocytes, macrophages, NK cells, myeloid-derived dendritic cells, microglia, activated lymphocytes, and mouse B-1 cells. The expression is up-regulated on activated neutrophils at the same time that L-selectin is shed from the cell surface. The M1/70 antibody is used for the detection of monocytes, granulocytes, and a subset of natural killer cells in human peripheral blood.M1/70 blocks C3bi binding and cell adherence, but not cell-mediated lysis and it cross-reacts with human CD11b.
NCBI Gene ID
3684
Swiss Prot
P11215
Host
Rat
Reactivity
Human, Mouse
Clonality
Monoclonal
Clone
M1/70
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Rat IgG2b, kappa
Specificity
The M1/70 monoclonal antibody specifically reacts with the 170 kDa alphaM integrin chain of mouse CD11b from the Mac-1 integrin (CD11b/CD18) .
Symbol
ITGAM
NCBI Official Name
Integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Organism
Homo sapiens
Background Reference 01
Sanchez-Madrid, F., Simon, P., Thompson, S., Springer, T. A. (1983) . Mapping of antigenic and functional epitopes on the alpha-and beta-subunits of two related mouse glycoproteins involved in cell interactions, LFA-1 and Mac-1.The Journal of experimental medicine,158 (2), 586-602.
Background Reference 02
Ault, K. A., Springer, T. A. (1981) . Cross-reaction of a rat-anti-mouse phagocyte-specific monoclonal antibody (anti-Mac-1) with human monocytes and natural killer cells.The Journal of Immunology,126 (1), 359-364.
Background Reference 03
Springer, T., Galfre, G., Secher, D. S., Milstein, C. (1978) . Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens.European journal of immunology,8 (8), 539-551.
Other Product Names
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM
Tested Applications
Flow, Functional Assays, IHC, IF, IP
Physical Properties
Liquid

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