CD11b Antibody

• Background:

  CD11b is the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3') . The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

• NCBI Gene ID:

  3684

• Swiss Prot:

  P11215

• Accession Number:

  P11215

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CD11b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the N-terminal region of human CD11b.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  127 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ITGAM

• NCBI Official Name:

  Integrin alpha-M

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gjelstrup, L.C., et al. J. Immunol. 185 (7) :4154-4168 (2010)

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Warchol, T., et al. DNA Cell Biol. (2010) In press :

• Background Reference 04:

  Fan, Y., et al.Eur Acad Dermatol Venereol (2010) In press :

• Other Product Names:

  Integrin alpha-M, CD11 antigen-like family member B, CR-3 alpha chain, Cell surface glycoprotein MAC-1 subunit alpha, Leukocyte adhesion receptor MO1, Neutrophil adherence receptor, CD11b, ITGAM, CD11B, CR3A

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  1708572

• Physical Properties:

  Liquid