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CD11b Antibody [ICRF44]

CAT: 0223-76-087Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-76-087Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta2) a complex known as Mac-1. CD11b is expressed on the surface of activated lymphocytes, a subset of natural killer cells, granulocytes, and monocytes. It functions as a receptor in cell-cell and cell-matrix interactions and as a receptor for iC3b, ICAM-1, ICAM-2, and ICAM-3 intercellular adhesion molecules.
NCBI Gene ID
3684
Swiss Prot
P11215
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Clone
ICRF44
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration
Batch dependent
Buffer
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Fragment
Mouse IgG1, kappa
Specificity
The ICRF44 monoclonal antibody specifically reacts with the 165 kDa human adhesion glycoprotein CD11b, which forms, together with the 95 kDa CD18 (integrin beta2) a complex known as Mac-1.
Symbol
ITGAM
NCBI Official Name
Integrin, alpha M (complement component 3 receptor 3 subunit)
NCBI Organism
Homo sapiens
Background Reference 01
Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997) .The leucocyte antigen factsbook. Academic Press.
Background Reference 02
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Background Reference 03
Sotiriou, S. N., Orlova, V. V., Al-Fakhri, N., Ihanus, E., Economopoulou, M., Isermann, B., ... Chavakis, T. (2006) . Lipoprotein (a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin.The FASEB journal,20 (3), 559-561.
Other Product Names
CR3A, MO1A, CD11B, MAC-1, MAC1A, SLEB6, ITGAM
Tested Applications
Flow, Functional Assays, IF, IP, WB
Physical Properties
Liquid

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