NFkB p100 / p52 (Ab 866) Antibody

• Background:

  NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κ -B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κ -B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.

• NCBI Gene ID:

  4791

• Swiss Prot:

  Q00653

• Accession Number:

  NP_001070961.1

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  NFkB-p100/p52 (Ab-866) antibody was raised against a peptide sequence around aa.864~868 (E-D-S-A-Y) derived from Human NFκ B-p100/p52.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer

• Purification:

  Antibodies were purified by affinity-chromatography using epitope-specific peptide.

• Concentration:

  1 mg/mL

• Buffer:

  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store antibody at -20˚ C for up to one year.

• Calculated Molecular Weight:

  120 kDa

• Specificity:

  This antibody detects endogenous level of total NFκ B-p100/p52 protein.

• Applications Notes:

  Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

• Symbol:

  NFKB2

• NCBI Official Name:

  Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Qu Z, et al. (2004) J Biol Chem. 279 (43) : 44563-44572. Xiao G, et al. (2001) Mol Cell. 7 (2) : 401-409. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.

• Other Product Names:

  P52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2, EIF4F, EIF4G, EIF4GI, DNA-binding factor KBF2, Lymphocyte translocation chromosome 10, Lyt10, NFKB2

• Tested Applications:

  WB, IHC, IF

• Protein ID:

  117320540

• Physical Properties:

  Liquid