NFkB p100 / p52 Antibody

• Background:

  This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) . The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  4791

• Swiss Prot:

  Q00653

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human NFkB p100 / p52

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Transcription

• Purification:

  Affinity purification

• Positive Control:

  HT-29

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 33kDa

• Fragment:

  IgG

• Symbol:

  NFKB2

• Positive Control 2:

  A-549

• Positive Control 3:

  HeLa

• NCBI Official Name:

  Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  NFKB2, p52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid