P100 Antibody

CAT: 0223-60-988Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-60-988Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The nuclear protein p100 is a proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M. Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. The full-length cDNA encodes a 747-amino acid protein with a putative ATP/GTP-binding site motif. RT-PCR analysis demonstrated strong expression of in lung carcinoma cell lines but not in normal lung tissues. Expression was also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney. P100 is also correlated to cancer prognosis.
NCBI Gene ID
22974
Swiss Prot
Q9ULW0
Accession Number
Q9ULW0
Host
Rabbit
Reactivity
Human
Immunogen
This P100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-382 amino acids from human P100.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
86 kDa
Fragment
Rabbit Ig
Symbol
TPX2
NCBI Official Name
Targeting protein for Xklp2
NCBI Organism
Homo sapiens
Background Reference 01
Ota, T., et al., Nat. Genet. 36 (1) :40-45 (2004) .
Background Reference 02
Heidebrecht, H.J., et al., Mol. Cancer Res. 1 (4) :271-279 (2003) .
Background Reference 03
Garrett, S., et al., Curr. Biol. 12 (23) :2055-2059 (2002) .
Background Reference 04
Gruss, O.J., et al., Nat. Cell Biol. 4 (11) :871-879 (2002) .
Other Product Names
Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519
Tested Applications
WB, IHC-P
Protein ID
13124096
Physical Properties
Liquid

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