Products for Research Use Only
RegisterLogin

NFKB Antibody

CAT: 0223-60-327Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-60-327Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
4790
Swiss Prot
P19838
Accession Number
P19838
Host
Rabbit
Reactivity
Human
Immunogen
This NFKB (p105) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-937 amino acids from the C-terminal region of human NFKB (p105) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Immunology, Signal Transduction, Inflammasomes
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
105 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NFKB1
NCBI Official Name
Nuclear factor NF-kappa-B p105 subunit
NCBI Organism
Homo sapiens
Background Reference 01
Beshir, A.B., et al. Cancer Lett. 299 (2) :137-149 (2010)
Background Reference 02
Song, C., et al. Virology 407 (2) :268-280 (2010)
Background Reference 03
Gonsalves, C., et al. J. Immunol. 185 (10) :6253-6264 (2010)
Background Reference 04
Kingeter, L.M., et al. J. Immunol. 185 (8) :4520-4524 (2010)
Other Product Names
Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, Nuclear factor NF-kappa-B p50 subunit, NFKB1
Tested Applications
WB
Protein ID
21542418
Physical Properties
Liquid

Related Products

CatalogName
18-945NFkB p100 / p52 Antibody
19-737NFkB p100 / p52 Antibody
79-264NFkB p65 (Ab 536) Antibody
79-200NFkB p65 (phospho Ser529) Antibody
79-182NFkB p65 (phospho Thr505) Antibody
79-108NFkB p65 (phospho Thr435) Antibody
79-107NFkB p65 (phospho Thr254) Antibody
79-263NFkB p65 (Ab 468) Antibody
79-384NFkB p65 (Ab 311) Antibody
79-262NFkB p65 (Ab 435) Antibody

Alternative Products

CatalogName
OACD05966-1MLNFKB Antibody
20R-2200NFKB p100 antibody
20R-2459NFKB p105 antibody
70R-37454NFkB p65 antibody
20R-1520NFkB p50 antibody
20R-2198NFKB-p65 antibody

Popular Products