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Rb (phospho Ser807) Antibody

CAT: 0223-79-163Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-163Size:0.1 mg
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Background
Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. In case of viral infections, interactions with SV40 large T antigen, HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
NCBI Gene ID
5925
Swiss Prot
P06400
Accession Number
NP_000312.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Rb (Phospho-Ser807) antibody was raised against a peptide sequence around phosphorylation site of serine 807 (Y-I-S (p) -P-L) derived from Human Rb.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Phospho-Specific, Cell Cycle
Purification
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
Phospho-Specific
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
110 kDa
Specificity
This antibody detects endogenous level of Rb only when phosphorylated at serine 807.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Symbol
RB1
NCBI Official Name
Retinoblastoma 1
NCBI Organism
Homo sapiens
Background Reference 01
Roesch A, et al. (2005) Mod Pathol. 18 (4) : 565-572. Chadee DN, et al. (2004) Nat Cell Biol. 6 (8) : 770-776. Knudsen ES, et al. (1997) Mol Cell Biol. 17 (10) : 5771-5783. Knudsen ES, et al. (1996) J Biol Chem. 271 (14) : 8313-8320.
Other Product Names
RB, pRb, OSRC, pp110, p105-Rb, ERYF1, GF1, P105-RB, PP105, PP110, RB-1, RB1
Tested Applications
WB, IHC
Protein ID
108773787
Physical Properties
Liquid

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