TYROBP Antibody

• Background:

  TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.

• NCBI Gene ID:

  7305

• Swiss Prot:

  O43914

• Accession Number:

  O43914

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TYROBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TYROBP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  12 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  TYROBP

• NCBI Official Name:

  TYRO protein tyrosine kinase-binding protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, X., et al. Blood 113 (14) :3226-3234 (2009)

• Background Reference 02:

  Sulonen, A.M., et al. J. Neuroimmunol. 206 (1-2), 86-90 (2009)

• Background Reference 03:

  Lanier, L.L. Immunol. Rev. 227 (1) :150-160 (2009)

• Background Reference 04:

  Schleinitz, N., et al. PLoS ONE (7), E6264 (2009)

• Other Product Names:

  TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP

• Tested Applications:

  WB, IHC-P, Flow

• Physical Properties:

  Liquid