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TYROBP Antibody

CAT: 0223-64-155Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-155Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TYROBP encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL.
NCBI Gene ID
7305
Swiss Prot
O43914
Accession Number
O43914
Host
Rabbit
Reactivity
Human
Immunogen
This TYROBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-113 amino acids from the C-terminal region of human TYROBP.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
12 kDa
Fragment
Rabbit Ig
Symbol
TYROBP
NCBI Official Name
TYRO protein tyrosine kinase-binding protein
NCBI Organism
Homo sapiens
Background Reference 01
Chen, X., et al. Blood 113 (14) :3226-3234 (2009)
Background Reference 02
Sulonen, A.M., et al. J. Neuroimmunol. 206 (1-2), 86-90 (2009)
Background Reference 03
Lanier, L.L. Immunol. Rev. 227 (1) :150-160 (2009)
Background Reference 04
Schleinitz, N., et al. PLoS ONE (7), E6264 (2009)
Other Product Names
TYRO protein tyrosine kinase-binding protein, DNAX-activation protein 12, Killer-activating receptor-associated protein, KAR-associated protein, TYROBP, DAP12, KARAP
Tested Applications
WB, IHC-P, Flow
Physical Properties
Liquid

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