Products for Research Use Only
RegisterLogin

HSD11B2 Antibody

CAT: 0223-64-100Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-64-100Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
NCBI Gene ID
3291
Swiss Prot
P80365
Accession Number
P80365
Host
Rabbit
Reactivity
Human
Immunogen
This HSD11B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-306 amino acids from the Central region of human HSD11B2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
44 kDa
Fragment
Rabbit Ig
Symbol
HSD11B2
NCBI Official Name
Corticosteroid 11-beta-dehydrogenase isozyme 2
NCBI Organism
Homo sapiens
Background Reference 01
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010)
Background Reference 02
Ni, X.T., et al. Placenta 30 (12) :1023-1028 (2009)
Background Reference 03
Mericq, V., et al. Eur. J. Endocrinol. 161 (3) :419-425 (2009)
Background Reference 04
Stark, M.J., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 (2), R510-R514 (2009)
Other Product Names
Corticosteroid 11-beta-dehydrogenase isozyme 2, 111-, 11-beta-hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type II, -HSD11 type II, NAD-dependent 11-beta-hydroxysteroid dehydrogenase, 11-beta-HSD, HSD11B2, HSD11K
Tested Applications
WB, IHC-P, Flow
Protein ID
30316367
Physical Properties
Liquid

Related Products

CatalogName
42-861Hsd11b1 Antibody
26-069HSD11B1 Antibody
61-801HSD17B2 Antibody
45-748HSD11B1 Antibody
63-983HSD17B3 Antibody
13-829HSD17B1 Antibody
55-870HSD11B1L Antibody
58-560HSD17B1 Antibody
63-906HSD17B12 Antibody
29-632HSD17B1 Antibody

Alternative Products

CatalogName
70R-2912HSD11B2 antibody

Popular Products