CYTH3 Antibody

• Background :

  This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.

• NCBI Gene ID :

  9265

• Swiss Prot :

  O43739

• Accession Number :

  O43739

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This CYTH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-400 amino acids from the C-terminal region of human CYTH3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  46 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  CYTH3

• NCBI Official Name :

  Cytohesin-3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Morishige, M., et al. Nat. Cell Biol. 10 (1) :85-92 (2008)

• Background Reference 02 :

  Poirier, M.B., et al. Mol. Endocrinol. 19 (8) :1991-2005 (2005)

• Background Reference 03 :

  Nevrivy, D.J., et al. J. Biol. Chem. 275 (22) :16827-16836 (2000)

• Background Reference 04 :

  Ogasawara, M., et al. J. Biol. Chem. 275 (5) :3221-3230 (2000)

• Other Product Names :

  Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CYTH3, ARNO3, GRP1, PSCD3

• Tested Applications :

  WB

• Physical Properties :

  Liquid