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CYTH3 Antibody

CAT: 0223-64-059Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-64-059Size:400 µL
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Background
This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.
NCBI Gene ID
9265
Swiss Prot
O43739
Accession Number
O43739
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This CYTH3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 371-400 amino acids from the C-terminal region of human CYTH3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CYTH3
NCBI Official Name
Cytohesin-3
NCBI Organism
Homo sapiens
Background Reference 01
Morishige, M., et al. Nat. Cell Biol. 10 (1) :85-92 (2008)
Background Reference 02
Poirier, M.B., et al. Mol. Endocrinol. 19 (8) :1991-2005 (2005)
Background Reference 03
Nevrivy, D.J., et al. J. Biol. Chem. 275 (22) :16827-16836 (2000)
Background Reference 04
Ogasawara, M., et al. J. Biol. Chem. 275 (5) :3221-3230 (2000)
Other Product Names
Cytohesin-3, ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CYTH3, ARNO3, GRP1, PSCD3
Tested Applications
WB
Physical Properties
Liquid

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