CYTH1 Antibody

• Background:

  The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2.

• NCBI Gene ID:

  9267

• Swiss Prot:

  Q15438

• Accession Number:

  Q15438

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYTH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human CYTH1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CYTH1

• NCBI Official Name:

  Cytohesin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  El Azreq, M.A., et al. J. Immunol. 184 (2) :637-649 (2010)

• Background Reference 02:

  Quast, T., et al. Blood 113 (23) :5801-5810 (2009)

• Background Reference 03:

  Sendide, K., et al. J. Immunol. 174 (7) :4210-4219 (2005)

• Background Reference 04:

  Boehm, T., et al. EMBO J. 22 (5) :1014-1024 (2003)

• Other Product Names:

  Cytohesin-1, PH, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1, CYTH1, D17S811E, PSCD1

• Tested Applications:

  WB

• Protein ID:

  2498175

• Physical Properties:

  Liquid