LFNG Antibody

• Background:

  LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150) .

• NCBI Gene ID:

  3955

• Swiss Prot:

  Q8NES3

• Accession Number:

  Q8NES3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This LFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  42 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  LFNG

• NCBI Official Name:

  Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dunwoodie, S.L. Biochim. Biophys. Acta 1792 (2) :100-111 (2009)

• Background Reference 02:

  Reedijk, M., et al. Int. J. Oncol. 33 (6) :1223-1229 (2008)

• Background Reference 03:

  Sparrow, D.B., et al. Am. J. Hum. Genet. 78 (1) :28-37 (2006)

• Background Reference 04:

  Cole, S.E., et al. Dev. Cell 3 (1) :75-84 (2002)

• Other Product Names:

  Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  27734417

• Physical Properties:

  Liquid