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LFNG Antibody

CAT: 0223-63-988Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-988Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LFNG belongs to evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This protein is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150) .
NCBI Gene ID
3955
Swiss Prot
Q8NES3
Accession Number
Q8NES3
Host
Rabbit
Reactivity
Human
Immunogen
This LFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human LFNG.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
42 kDa
Fragment
Rabbit Ig
Symbol
LFNG
NCBI Official Name
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
NCBI Organism
Homo sapiens
Background Reference 01
Dunwoodie, S.L. Biochim. Biophys. Acta 1792 (2) :100-111 (2009)
Background Reference 02
Reedijk, M., et al. Int. J. Oncol. 33 (6) :1223-1229 (2008)
Background Reference 03
Sparrow, D.B., et al. Am. J. Hum. Genet. 78 (1) :28-37 (2006)
Background Reference 04
Cole, S.E., et al. Dev. Cell 3 (1) :75-84 (2002)
Other Product Names
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, LFNG
Tested Applications
WB, IHC-P, Flow
Protein ID
27734417
Physical Properties
Liquid

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