SLC8A1 Antibody

CAT: 0223-63-711Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-711Size:400 µL
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Background
In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) centration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane) . During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) -Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.
NCBI Gene ID
6546
Swiss Prot
P32418
Accession Number
P32418
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This SLC8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human SLC8A1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
109 kDa
Fragment
Rabbit Ig
Symbol
SLC8A1
NCBI Official Name
Sodium/calcium exchanger 1
NCBI Organism
Homo sapiens
Background Reference 01
Palty, R., et.al., Proc. Natl. Acad. Sci. U.S.A. 107 (1), 436-441 (2010) Kepp, K., et.al., BMC Med. Genet. 11, 15 (2010)
Other Product Names
Sodium/calcium exchanger 1, Na (+) /Ca (2+) -exchange protein 1, Solute carrier family 8 member 1, SLC8A1, CNC, NCX1
Tested Applications
WB, IHC-P, Flow
Protein ID
12644210
Physical Properties
Liquid

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