SLC8A1 Antibody

• Background:

  In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) centration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane) . During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) -Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

• NCBI Gene ID:

  6546

• Swiss Prot:

  P32418

• Accession Number:

  P32418

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This SLC8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human SLC8A1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  109 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SLC8A1

• NCBI Official Name:

  Sodium/calcium exchanger 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Palty, R., et.al., Proc. Natl. Acad. Sci. U.S.A. 107 (1), 436-441 (2010) Kepp, K., et.al., BMC Med. Genet. 11, 15 (2010)

• Other Product Names:

  Sodium/calcium exchanger 1, Na (+) /Ca (2+) -exchange protein 1, Solute carrier family 8 member 1, SLC8A1, CNC, NCX1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  12644210

• Physical Properties:

  Liquid