SLC8A1 Polyclonal Antibody

• Background:

  In cardiac myocytes, Ca (2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca (2+) concentration during contraction is primarily due to release of Ca (2+) from intracellular stores. However, some Ca (2+) also enters the cell through the sarcolemma (plasma membrane) . During relaxation, Ca (2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca (2+) that entered across the sarcolemma must be extruded from the cell. The Na (+) -Ca (2+) exchanger is the primary mechanism by which the Ca (2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

• Description:

  This is a SLC8A1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  SLC8A1, NCX1

• Gene ID:

  6546

• Swiss Prot:

  P32418

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human SLC8A1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:1000-1:2000, IHC 1:50-1:200

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  46kDa/50kDa/54kDa

• Observed Molecular Weight:

  55KDa

• Host or Source:

  Rabbit

• Isotype:

  IgG