BMI1 Antibody

• Background:

  Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

• NCBI Gene ID:

  100532731648

• Swiss Prot:

  P35226

• Accession Number:

  P35226

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This BMI1 antibody is generated from rabbits immunized with BMI1 recombinant protein.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  37 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  BMI1

• NCBI Official Name:

  Polycomb complex protein BMI-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chagraoui J., et.al., Genes Dev. 20:2110-2120 (2006) .

• Other Product Names:

  Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51, BMI1, PCGF4, RNF51

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  22258801

• Physical Properties:

  Liquid