Products for Research Use Only
RegisterLogin

BMI-1 Antibody

CAT: 0223-3755-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-3755-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
BMI-1 Antibody: The transcriptional repressor BMI-1 was first identified as a proto-oncogene frequently activated by Moloney murine leukemia proviral insertions in mice and cooperating with c-myc in the generation of mouse lymphomas. BMI-1 is involved in segment specification, cell growth and maintenance, transcriptional regulation, and chromatin modification. A major target of BMI-1 is the ink4a locus which encodes tumor suppressor proteins p16 and p19Arf, which are important in tumor progression and thought to be critical in cell proliferation and senescence. Recent studies have also shown that BMI-1 is required for the maintenance of adult normal and leukemic stem cells, suggesting that BMI-1 could an attractive therapeutic target for stem cell proliferation and renewal as well as for anti-cancer strategies.
NCBI Gene ID
648
Swiss Prot
P35226
Accession Number
P35226
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Neuroscience
Purification
BMI-1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1204 - K562 Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (100%)
Buffer
BMI-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
BMI-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
BMI1
Positive Control 2
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
BMI1 polycomb ring finger oncogene
NCBI Organism
Homo sapiens
Background Reference 01
Alkema MJ, Wiegant J, Raap AK, et al. Characterization and chromosomal localization of the human proto-oncogene BMI-1. Hum. Mol. Genet. 1993; 2:1597-603.
Background Reference 02
Jacobs JJ, Kieboom K, Marino S, et al. The oncogene and polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999; 397:164-8.
Background Reference 03
Lessard J and Sauvageau G. BMI-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003; 255-60.
Other Product Names
BMI-1 Antibody: PCGF4, RNF51, FLVI2/BMI1, PCGF4, Polycomb complex protein BMI-1, Polycomb group RING finger protein 4
Tested Applications
ELISA, WB, ICC, IF
Protein ID
22258801
Physical Properties
Liquid

Related Products

CatalogName
3755PBMI-1 Peptide
61-406BMI1 Antibody
43-563BMI1 Antibody
63-629BMI1 Antibody
13-080BMI1 Antibody
43-567BMI1 Antibody
36-149BAFF Antibody [1-35-1]
33-439CD99 Antibody [HO36-1.1]
33-215TTF-1 Antibody [8G7G3/1]
34-055TIA-1 Antibody [TRIA1-1]

Alternative Products

CatalogName
V7517-20UGBMI-1 Antibody
6150-100BMI 1 Antibody
A00313Anti-BMI-1 Antibody
RA10854-01Bmi-1 Monoclonal Antibody
APR00333GPolyclonal BMI 1 Antibody
MBS565840-01BMI 1 polyclonal antibody
C42097-01Bmi-1 Antibody (F270)
APR06395GPolyclonal BMI-1 Antibody
24394BMI Antibody
TMAY-00110Anti-BMI-1 Antibody (9H107)

Popular Products