DERL1 Antibody

• Background:

  Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

• NCBI Gene ID:

  79139

• Swiss Prot:

  Q9BUN8

• Accession Number:

  Q9BUN8

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DERL1

• NCBI Official Name:

  Derlin-1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Oda Y., et.al., J. Cell Biol. 172:383-393 (2006) . Ye Y., et.al., Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138 (2005) .

• Other Product Names:

  Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1, DERL1, DER1

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  50400630

• Physical Properties:

  Liquid