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DERL1 Antibody

CAT: 0223-63-625Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-625Size:400 µL
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Background
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
NCBI Gene ID
79139
Swiss Prot
Q9BUN8
Accession Number
Q9BUN8
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This DERL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 224-251 amino acids from the C-terminal region of human DERL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
DERL1
NCBI Official Name
Derlin-1
NCBI Organism
Homo sapiens
Background Reference 01
Oda Y., et.al., J. Cell Biol. 172:383-393 (2006) . Ye Y., et.al., Proc. Natl. Acad. Sci. U.S.A. 102:14132-14138 (2005) .
Other Product Names
Derlin-1, Degradation in endoplasmic reticulum protein 1, DERtrin-1, Der1-like protein 1, DERL1, DER1
Tested Applications
WB, IHC-P, Flow
Protein ID
50400630
Physical Properties
Liquid

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