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Mouse Derl2 Antibody

CAT: 0223-60-461Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-60-461Size:400 µL
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Background
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity) .
NCBI Gene ID
116891
Swiss Prot
Q8BNI4
Accession Number
Q8BNI4
Host
Rabbit
Reactivity
Mouse
Immunogen
This Mouse Derl2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-219 amino acids from the C-terminal region of mouse Derl2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
28 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
Derl2
NCBI Official Name
Derlin-2
NCBI Organism
Mus musculus
Background Reference 01
Schaheen, B., et al. J. Cell. Sci. 122 (PT 13), 2228-2239 (2009) :
Background Reference 02
Oda, Y., et al. J. Cell Biol. 172 (3) :383-393 (2006)
Background Reference 03
Lilley, B.N., et al. Proc. Natl. Acad. Sci. U.S.A. 102 (40) :14296-14301 (2005)
Background Reference 04
Kaput, J., et al. Physiol. Genomics 18 (3) :316-324 (2004)
Other Product Names
Derlin-2, Degradation in endoplasmic reticulum protein 2, Der1-like protein 2, F-LANa, Derl2, Der2, Flana
Tested Applications
WB
Physical Properties
Liquid

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