PPP3CC Antibody

CAT: 0223-63-487Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-487Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca (2+) -dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity) .
NCBI Gene ID
5533
Swiss Prot
P48454
Accession Number
P48454
Host
Rabbit
Reactivity
Human
Immunogen
This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-512 amino acids from the C-terminal region of human PPP3CC.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
58 kDa
Fragment
Rabbit Ig
Symbol
PPP3CC
NCBI Official Name
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
NCBI Organism
Homo sapiens
Background Reference 01
Eastwood, S.L., et al., Biol. Psychiatry 57 (7) :702-710 (2005) .
Background Reference 02
Gerber, D.J., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (15) :8993-8998 (2003) .
Background Reference 03
Bennasser, Y., et al., Virology 303 (1) :174-180 (2002) .
Background Reference 04
Esau, C., et al., J. Exp. Med. 194 (10) :1449-1459 (2001) .
Other Product Names
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3
Tested Applications
WB, IHC-P
Protein ID
257051041
Physical Properties
Liquid

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