PPP3CC Antibody

• Background:

  Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca (2+) -dependent modifier of phosphorylation status. In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively. At least 3 genes, calcineurin A-alpha, calcineurin A-beta, and calcineurin A-gamma, have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity) .

• NCBI Gene ID:

  5533

• Swiss Prot:

  P48454

• Accession Number:

  P48454

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PPP3CC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 482-512 amino acids from the C-terminal region of human PPP3CC.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  58 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PPP3CC

• NCBI Official Name:

  Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Eastwood, S.L., et al., Biol. Psychiatry 57 (7) :702-710 (2005) .

• Background Reference 02:

  Gerber, D.J., et al., Proc. Natl. Acad. Sci. U.S.A. 100 (15) :8993-8998 (2003) .

• Background Reference 03:

  Bennasser, Y., et al., Virology 303 (1) :174-180 (2002) .

• Background Reference 04:

  Esau, C., et al., J. Exp. Med. 194 (10) :1449-1459 (2001) .

• Other Product Names:

  Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform, CAM-PRP catalytic subunit, Calcineurin, testis-specific catalytic subunit, Calmodulin-dependent calcineurin A subunit gamma isoform, PPP3CC, CALNA3, CNA3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  257051041

• Physical Properties:

  Liquid