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PPP1CB Antibody

CAT: 0223-57-323Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-323Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.
NCBI Gene ID
5500
Swiss Prot
P62140
Accession Number
P62140
Host
Rabbit
Reactivity
Human
Immunogen
This PPP1CB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 298-327 amino acids from the C-terminal region of human PPP1CB.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse, Pig, Rabbit, Rat, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
37 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PPP1CB
NCBI Official Name
Serine/threonine-protein phosphatase PP1-beta catalytic subunit
NCBI Organism
Homo sapiens
Background Reference 01
Lee, J.H., et al. J. Biol. Chem. 285 (32) :24466-24476 (2010)
Background Reference 02
Fujiki, R., et al. Nature 459 (7245) :455-459 (2009)
Background Reference 03
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18 (1) :255-259 (2009)
Background Reference 04
Sueyoshi, T., et al. Mol. Pharmacol. 73 (4) :1113-1121 (2008)
Other Product Names
Serine/threonine-protein phosphatase PP1-beta catalytic subunit, PP-1B, PPP1CD, PPP1CB
Tested Applications
WB
Protein ID
49065814
Physical Properties
Liquid

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