PP2A alpha Antibody

• Background:

  PPP2CA/B represents the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits.

• NCBI Gene ID:

  5515

• Swiss Prot:

  P67775

• Accession Number:

  P67775

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PP2A alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 274-304 amino acids from the C-terminal region of human PP2A alpha.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Mouse, Pig, Rabbit, Rat, Drosophila

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  36 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PPP2CA

• NCBI Official Name:

  Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gergs, U., et al., J. Biol. Chem. 279 (39) :40827-40834 (2004) .

• Background Reference 02:

  Prickett, T.D., et al., J. Biol. Chem. 279 (37) :38912-38920 (2004) .

• Background Reference 03:

  Scott, G.K., et al., EMBO J. 22 (23) :6234-6244 (2003) .

• Background Reference 04:

  Rao, R.K., et al., Biochem. Biophys. Res. Commun. 293 (1) :610-616 (2002) .

• Other Product Names:

  Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, PP2A-alpha, Replication protein C, RP-C, PPP2CA

• Tested Applications:

  WB, IHC-P

• Protein ID:

  54038809

• Physical Properties:

  Liquid