AP2 alpha Antibody

• Background:

  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2 alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle.

• NCBI Gene ID:

  7020

• Swiss Prot:

  P05549

• Accession Number:

  P05549

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This AP2 alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human AP2 alpha.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  48 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TFAP2A

• NCBI Official Name:

  Transcription factor AP-2-alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Provenzano, M.J., Exp. Mol. Pathol. 83 (2), 277-282 (2007)

• Background Reference 02:

  Tan, Y.R., Biochem. J. 405 (1), 131-137 (2007)

• Background Reference 03:

  Liu, H., EMBO Rep. (4), 394-400 (2007)

• Background Reference 04:

  Han, S., J. Biol. Chem. 282 (11), 7961-7972 (2007)

• Other Product Names:

  Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2, TFAP2A, AP2TF, TFAP2

• Tested Applications:

  WB

• Protein ID:

  135302

• Physical Properties:

  Liquid