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PTP alpha Antibody

CAT: 0223-63-460Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-460Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ?it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.
NCBI Gene ID
5786
Swiss Prot
P18433
Accession Number
P18433
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This PTP alpha antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-120 amino acids from the N-terminal region of human PTP alpha.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
91 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PTPRA
NCBI Official Name
Receptor-type tyrosine-protein phosphatase alpha
NCBI Organism
Homo sapiens
Background Reference 01
Deloukas, P., et al., Nature 414 (6866) :865-871 (2001) .
Background Reference 02
Kaplan, R., et al., Proc. Natl. Acad. Sci. U.S.A. 87 (18) :7000-7004 (1990) .
Background Reference 03
Krueger, N.X., et al., EMBO J. 9 (10) :3241-3252 (1990) .
Background Reference 04
Sap, J., et al., Proc. Natl. Acad. Sci. U.S.A. 87 (16) :6112-6116 (1990) .
Other Product Names
Receptor-type tyrosine-protein phosphatase alpha, Protein-tyrosine phosphatase alpha, R-PTP-alpha, PTPRA, PTPA, PTPRL2
Tested Applications
WB
Protein ID
126467
Physical Properties
Liquid

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