DUSP8 Antibody

CAT: 0223-63-478Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-478Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.
NCBI Gene ID
1850
Swiss Prot
Q13202
Accession Number
Q13202
Host
Rabbit
Reactivity
Human
Immunogen
This DUSP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-487 amino acids from the C-terminal region of human DUSP8.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Symbol
DUSP8
NCBI Official Name
Dual specificity protein phosphatase 8
NCBI Organism
Homo sapiens
Background Reference 01
Berger, I.R., et al., Cancer Genet. Cytogenet. 159 (2) :155-159 (2005) .
Background Reference 02
Hink, R.L., et al., Genomics 8 (3) :305-312 (2003) .
Background Reference 03
Nesbit, M.A., et al., Genomics 42 (2) :284-294 (1997) .
Background Reference 04
Martell, K.J., et al., J. Neurochem. 65 (4) :1823-1833 (1995) .
Other Product Names
Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5, DUSP8, C11orf81, VH5
Tested Applications
WB, IHC-P
Protein ID
223590200
Physical Properties
Liquid

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