DUSP8 Antibody

• Background:

  DUSP8 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP8 inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin.

• NCBI Gene ID:

  1850

• Swiss Prot:

  Q13202

• Accession Number:

  Q13202

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DUSP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 456-487 amino acids from the C-terminal region of human DUSP8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  66 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DUSP8

• NCBI Official Name:

  Dual specificity protein phosphatase 8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Berger, I.R., et al., Cancer Genet. Cytogenet. 159 (2) :155-159 (2005) .

• Background Reference 02:

  Hink, R.L., et al., Genomics 8 (3) :305-312 (2003) .

• Background Reference 03:

  Nesbit, M.A., et al., Genomics 42 (2) :284-294 (1997) .

• Background Reference 04:

  Martell, K.J., et al., J. Neurochem. 65 (4) :1823-1833 (1995) .

• Other Product Names:

  Dual specificity protein phosphatase 8, Dual specificity protein phosphatase hVH-5, DUSP8, C11orf81, VH5

• Tested Applications:

  WB, IHC-P

• Protein ID:

  223590200

• Physical Properties:

  Liquid