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DUSP3 Antibody

CAT: 0223-63-474Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-63-474Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. The gene for this protein maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.
NCBI Gene ID
1845
Swiss Prot
P51452
Accession Number
P51452
Host
Rabbit
Reactivity
Human
Immunogen
This DUSP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-185 amino acids from the C-terminal region of human DUSP3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
20 kDa
Fragment
Rabbit Ig
Symbol
DUSP3
NCBI Official Name
Dual specificity protein phosphatase 3
NCBI Organism
Homo sapiens
Background Reference 01
Alonso, A., et al., Nat. Immunol. 4 (1) :44-48 (2003) .
Background Reference 02
Alonso, A., et al., J. Biol. Chem. 276 (7) :4766-4771 (2001) .
Background Reference 03
Todd, J.L., et al., J. Biol. Chem. 274 (19) :13271-13280 (1999) .
Background Reference 04
Kamb, A., et al., Genomics 23 (1) :163-167 (1994) .
Other Product Names
Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase, VHR, DUSP3, VHR
Tested Applications
WB, IHC-P, Flow
Protein ID
1718191
Physical Properties
Liquid

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