DUSP9 Antibody

• Background :

  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus. [provided by RefSeq].

• NCBI Gene ID :

  1852

• Swiss Prot :

  Q99956

• Accession Number :

  Q99956

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This DUSP9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-329 amino acids from the C-terminal region of human DUSP9.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  42 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  DUSP9

• NCBI Official Name :

  Dual specificity protein phosphatase 9

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Voight, B.F., et al. Nat. Genet. 42 (7) :579-589 (2010)

• Background Reference 02 :

  Liu, Y., et al. Cancer Res. 67 (22) :10711-10719 (2007)

• Background Reference 03 :

  Ross, M.T., et al. Nature 434 (7031) :325-337 (2005)

• Background Reference 04 :

  Muda, M., et al. J. Biol. Chem. 272 (8) :5141-5151 (1997)

• Other Product Names :

  Dual specificity protein phosphatase 9, Mitogen-activated protein kinase phosphatase 4, MAP kinase phosphatase 4, MKP-4, DUSP9, MKP4

• Tested Applications :

  WB, IHC-P

• Protein ID :

  3913541

• Physical Properties :

  Liquid