DUSP4 Antibody

• Background:

  DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus.

• NCBI Gene ID:

  1846

• Swiss Prot:

  Q13115

• Accession Number:

  Q13115

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This DUSP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-361 amino acids from the C-terminal region of human DUSP4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  43 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DUSP4

• NCBI Official Name:

  Dual specificity protein phosphatase 4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Chen, P., et al., J. Biol. Chem. 276 (31) :29440-29449 (2001) .

• Background Reference 02:

  Smith, A., et al., Genomics 42 (3) :524-527 (1997) .

• Background Reference 03:

  Chu, Y., et al., J. Biol. Chem. 271 (11) :6497-6501 (1996) .

• Background Reference 04:

  King, A.G., et al., Oncogene 11 (12) :2553-2563 (1995) .

• Other Product Names:

  Dual specificity protein phosphatase 4, Dual specificity protein phosphatase hVH2, Mitogen-activated protein kinase phosphatase 2, MAP kinase phosphatase 2, MKP-2, DUSP4, MKP2, VH2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  2499745

• Physical Properties:

  Liquid