DUSP8 Antibody

CAT: 0223-18-181Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-18-181Size:100 µL
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Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
NCBI Gene ID
1850
Swiss Prot
Q13202
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein of human DUSP8
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
U-87MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 66kDa
Fragment
IgG
Applications Notes
WB: 1:200 - 1:1000
Symbol
DUSP8
Positive Control 2
Raji
Positive Control 3
A-431
NCBI Official Name
Dual specificity phosphatase 8
NCBI Organism
Homo sapiens
Other Product Names
DUSP8, dual specificity phosphatase 8, HB5, HVH8, HVH-5, H1 phosphatase, vaccinia virus homolog, serine/threonine specific protein phosphatase, C11orf81, VH5
Tested Applications
WB
Physical Properties
Liquid

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