DUSP8 Antibody

• Background:

  The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.

• NCBI Gene ID:

  1850

• Swiss Prot:

  Q13202

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein of human DUSP8

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-87MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 66kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:200 - 1:1000

• Symbol:

  DUSP8

• Positive Control 2:

  Raji

• Positive Control 3:

  A-431

• NCBI Official Name:

  Dual specificity phosphatase 8

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  DUSP8, dual specificity phosphatase 8, HB5, HVH8, HVH-5, H1 phosphatase, vaccinia virus homolog, serine/threonine specific protein phosphatase, C11orf81, VH5

• Tested Applications:

  WB

• Physical Properties:

  Liquid