YWHAB Antibody

• Background:

  YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

• NCBI Gene ID:

  7529

• Swiss Prot:

  P31946

• Accession Number:

  P31946

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 amino acids from the C-terminal region of human YWHAB.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Chicken, Monkey, Mouse, Rat, Zebrafish

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  28 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  YWHAB

• NCBI Official Name:

  14-3-3 protein beta/alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Komori, T., et al., Acta Neuropathol. 106 (1) :66-70 (2003) . Cavet, M.E., et al., J. Biol. Chem. 278 (20) :18376-18383 (2003) . Li, Y., et al., J. Biol. Chem. 278 (16) :13663-13671 (2003) . Shumway, S.D., et al., J. Biol. Chem. 278 (4) :2089-2092 (2003) . Parvaresch, S., et al., FEBS Lett. 532 (3) :357-362 (2002) .

• Other Product Names:

  14-3-3 protein beta/alpha, Protein 1054, Protein kinase C inhibitor protein 1, KCIP-1, 14-3-3 protein beta/alpha, N-terminally processed, YWHAB

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  1345590

• Physical Properties:

  Liquid