NME2 Antibody

• Background:

  NM2 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in skeletal muscle, and negligible expression in other mouse tissues examined.

• NCBI Gene ID:

  4831654364

• Swiss Prot:

  P22392

• Accession Number:

  P22392

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This NME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human NME2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  17 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NME2

• NCBI Official Name:

  Nucleoside diphosphate kinase B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Munier, A., et al., Exp. Cell Res. 289 (2) :295-306 (2003) .

• Background Reference 02:

  Kim, S.H., et al., Biochem. Biophys. Res. Commun. 296 (4) :970-975 (2002) .

• Background Reference 03:

  Okabe-Kado, J., et al., Leuk. Res. 26 (6) :569-576 (2002) .

• Background Reference 04:

  Godfried, M.B., et al., Oncogene 21 (13) :2097-2101 (2002) .

• Other Product Names:

  Nucleoside diphosphate kinase B, NDK B, NDP kinase B, C-myc purine-binding transcription factor PUF, Histidine protein kinase NDKB, nm23-H2, NME2, NM23B

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  127983

• Physical Properties:

  Liquid