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NME2 Antibody

CAT: 0223-63-385Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-385Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NM2 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in skeletal muscle, and negligible expression in other mouse tissues examined.
NCBI Gene ID
4831654364
Swiss Prot
P22392
Accession Number
P22392
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
This NME2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human NME2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
17 kDa
Fragment
Rabbit Ig
Symbol
NME2
NCBI Official Name
Nucleoside diphosphate kinase B
NCBI Organism
Homo sapiens
Background Reference 01
Munier, A., et al., Exp. Cell Res. 289 (2) :295-306 (2003) .
Background Reference 02
Kim, S.H., et al., Biochem. Biophys. Res. Commun. 296 (4) :970-975 (2002) .
Background Reference 03
Okabe-Kado, J., et al., Leuk. Res. 26 (6) :569-576 (2002) .
Background Reference 04
Godfried, M.B., et al., Oncogene 21 (13) :2097-2101 (2002) .
Other Product Names
Nucleoside diphosphate kinase B, NDK B, NDP kinase B, C-myc purine-binding transcription factor PUF, Histidine protein kinase NDKB, nm23-H2, NME2, NM23B
Tested Applications
WB, IHC-P, IF
Protein ID
127983
Physical Properties
Liquid

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