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NME1 Antibody

CAT: 0223-58-191Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-58-191Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
NCBI Gene ID
4830
Swiss Prot
P15531
Accession Number
P15531
Host
Rabbit
Reactivity
Human
Immunogen
This NME1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the Central region of human NME1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
17 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
NME1
NCBI Official Name
Nucleoside diphosphate kinase A
NCBI Organism
Homo sapiens
Background Reference 01
Boissan, M., et al. Cancer Res. 70 (19) :7710-7722 (2010)
Background Reference 02
Wang, P.H., et al. Gynecol. Oncol. 119 (1) :70-75 (2010)
Background Reference 03
Conery, A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107 (35) :15461-15466 (2010)
Background Reference 04
Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :
Other Product Names
Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23
Tested Applications
WB
Protein ID
127981
Physical Properties
Liquid

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