NME3 Antibody

• Background:

  NME3 mRNA is preferentially expressed at early stages of myeloid differentiation of highly purified CD34 (+) cells. Its constitutive expression in a myeloid precursor line, which is growth-factor dependent for both proliferation and differentiation, results in inhibition of granulocytic differentiation induced by granulocyte colony-stimulating factor and causes apoptotic cell death. These results appear consistent with a role for the NME3 gene in normal hematopoiesis and raise the possibility that its overexpression contributes to differentiation arrest, a feature of blastic transformation in chronic myelogenous leukemia.

• NCBI Gene ID:

  4832

• Swiss Prot:

  Q13232

• Accession Number:

  Q13232

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NME3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the Central region of human NME3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NME3

• NCBI Official Name:

  Nucleoside diphosphate kinase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Negroni, A., et al., Cell Death Differ. 7 (9) :843-850 (2000) .

• Background Reference 02:

  Martinez, R., et al., Cancer Res. 57 (6) :1180-1187 (1997) .

• Background Reference 03:

  Venturelli, D., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (16) :7435-7439 (1995) .

• Other Product Names:

  Nucleoside diphosphate kinase 3, NDK 3, NDP kinase 3, DR-nm23, Nucleoside diphosphate kinase C, NDPKC, nm23-H3, NME3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  21264477

• Physical Properties:

  Liquid