CYP2C8 Antibody

• Background:

  CYP2C8 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo (a) pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol.

• NCBI Gene ID:

  1558

• Swiss Prot:

  P10632

• Accession Number:

  P10632

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CYP2C8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-105 amino acids from the N-terminal region of human CYP2C8.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  CYP2C8

• NCBI Official Name:

  Cytochrome P450 2C8

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Adjei, G.O., Antimicrob. Agents Chemother. 52 (12), 4400-4406 (2008)

• Background Reference 02:

  Aquilante, C.L., Hum. Genomics (1), 7-16 (2008)

• Background Reference 03:

  Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)

• Other Product Names:

  Cytochrome P450 2C8, CYPIIC8, Cytochrome P450 IIC2, Cytochrome P450 MP-12, Cytochrome P450 MP-20, Cytochrome P450 form 1, S-mephenytoin 4-hydroxylase, CYP2C8

• Tested Applications:

  WB

• Protein ID:

  117225

• Physical Properties:

  Liquid