CYP2B6 Antibody

CAT: 0223-55-629Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-55-629Size:400 µL
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Background
This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
NCBI Gene ID
1555
Swiss Prot
P20813
Accession Number
P20813
Host
Rabbit
Reactivity
Human
Immunogen
This CYP2B6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-263 amino acids from the Central region of human CYP2B6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
56 kDa
Fragment
Rabbit Ig
Symbol
CYP2B6
NCBI Official Name
Cytochrome P450 2B6
NCBI Organism
Homo sapiens
Background Reference 01
Figueroa, S.C., et al. Ther Drug Monit 32 (5) :579-585 (2010)
Background Reference 02
Chou, M., et al. Antimicrob. Agents Chemother. 54 (10) :4432-4439 (2010)
Background Reference 03
Shimada, M., et al. Hum. Genet. 128 (4) :433-441 (2010)
Background Reference 04
Bunten, H., et al. Clin. Pharmacol. Ther. 88 (3) :383-389 (2010)
Other Product Names
Cytochrome P450 2B6, 11413-,4-cineole 2-exo-monooxygenase, CYPIIB6, Cytochrome P450 IIB1, CYP2B6
Tested Applications
WB, IHC-P, IF
Protein ID
117205
Physical Properties
Liquid

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