CYP2C19 Antibody

• Background :

  CYP2C19 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within its gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes.

• NCBI Gene ID :

  1557

• Swiss Prot :

  P33261

• Accession Number :

  P33261

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This CYP2C19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-108 amino acids from the N-terminal region of human CYP2C19.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Signal Transduction

• Purification :

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  56 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  CYP2C19

• NCBI Official Name :

  Cytochrome P450 2C19

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Shuldiner, A.R., JAMA 302 (8), 849-857 (2009) Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004)

• Other Product Names :

  Cytochrome P450 2C19, 11413-, (R) -limonene 6-monooxygenase, (S) -limonene 6-monooxygenase, (S) -limonene 7-monooxygenase, CYPIIC17, CYPIIC19, Cytochrome P450-11A, Cytochrome P450-254C, Mephenytoin 4-hydroxylase, CYP2C19

• Tested Applications :

  WB, IHC-P, IF

• Protein ID :

  60416369

• Physical Properties :

  Liquid