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PAK1 Antibody

CAT: 0223-63-291Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-63-291Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PAK1, a member of the STE20 subfamily of Ser/Thr protein kinases, acts on a variety of targets. It is likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. The protein interacts tightly with GTP-bound but not GDP-bound CDC42/P21 and RAC1. PAK1 binds to the caspase-cleaved p110 isoform of CDC2L1 and CDC2L2, p110C, but not the full-length proteins. It is a component of cytoplasmic complexes, which also contain PXN, ARHGEF6 and GIT1. The protein is autophosphorylated when activated by CDC42/p21. Structurally, the PAK1 contains 1 CRIB domain.
NCBI Gene ID
5058
Swiss Prot
Q13153
Accession Number
Q13153
Host
Rabbit
Reactivity
Human
Immunogen
This PAK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from human PAK1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat, Rabbit, Xenopus
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
61 kDa
Fragment
Rabbit Ig
Symbol
PAK1
NCBI Official Name
Serine/threonine-protein kinase PAK 1
NCBI Organism
Homo sapiens
Background Reference 01
Chen, S., et al., J. Biol. Chem. 278 (22) :20029-20036 (2003) .
Background Reference 02
Sells, M.A., et al., Curr. Biol. 7 (3) :202-210 (1997) .
Background Reference 03
Brown, J.L., et al., Curr. Biol. 6 (5) :598-605 (1996) .
Other Product Names
Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, PAK-1, p65-PAK, PAK1
Tested Applications
WB, IHC-P, IF
Protein ID
90111767
Physical Properties
Liquid

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