MERTK Antibody

• Background:

  MERTK is a member of the MER/AXL/TYRO3 receptor kinase family and a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in MERTK gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP) .

• NCBI Gene ID:

  10461

• Swiss Prot:

  Q12866

• Accession Number:

  Q12866

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MERTK antibody is generated from rabbits immunized with a his tag recombinant protein of human MERTK.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Immunology, Neuroscience, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  110 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MERTK

• NCBI Official Name:

  Tyrosine-protein kinase Mer

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gal A., Li Y., Thompson D.A., Weir J., Orth U., Jacobson S.G.Nat. Genet. 26:270-271 (2000)

• Background Reference 02:

  Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Nature 434:724-731 (2005)

• Other Product Names:

  Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK, MER

• Tested Applications:

  WB, IHC-P, IF, Flow

• Protein ID:

  160332297

• Physical Properties:

  Liquid