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MERTK / Mer Recombinant Protein

CAT: 0223-11-309Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-11-309Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Tyrosine-protein kinase Mer (MERTK) is a member of the TYRO3/AXL/MER (TAM) receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs) -mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
CAS Number
9000-83-3
NCBI Gene ID
10461
Swiss Prot
Q12866
Accession Number
NP_006334.2
Tag
His Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>90% as determined by SDS-PAGE.
Buffer
PBS, pH7.4
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
54.5 kDa
Applications Notes
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 54.5 kDa. The protein migrates as 70-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
MERproto-oncogene, tyrosinekinase
NCBI Organism
Homo sapiens
Background Reference 01
Graham DK, et al. Cell Growth Differ. 1994. 5 (6) :647-57.
Background Reference 02
Shimojima M, et al. J Virol. 2006. 80 (20) :10109-16.
Other Product Names
MERTK, Mer
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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